An Experimental Study on Pharmacodynamics Interaction of Doramectin with Anticonvulsants and Anaesthetics in Mice

Avinash Tambotra, R. S. Telang, Chandresh Varshney, Pradeep Kumar, Madhukar Shivajirao Dama

Abstract


The present study was conducted to examine the pharmacodynamics interactions between doramectin and general anesthetics like diethyl ether and anticonvulsants like phenytoin and diazepam. The methods employed were supramaximal electroshock test (for phenytoin), chemical convulsion test and unconditioned response avoidance test (for diazepam) and different stages of anesthesia and duration of anesthesia (for diethyl ether). In supramaximal electroshock test phenytoin was equally effective in all the groups in controlling grand mal seizures. In chemical convulsion test no response to diazepam was observed in all the groups pretreated with doramectin. And in unconditioned response avoidance test only one mouse showed response to shock in doramectin 200µg/kg group similar to the control 2 group. However, no mouse showed response to shock in doramectin 600 µg/kg groups. No difference was observed in the time taken for exhibiting various stages of anesthesia in different groups in inhalant anesthesia. However the total duration of anesthesia was increased in doramectin (200 mg/kg) treated group (781.67±24.82 sec)) and the value was significantly high in doramectin (600 mg/kg) treated group (861.67±55.69 sec) as compared to 673.33±30.94 sec in control 2. The result suggests that doramectin prolongs the recovery from anesthesia but does not support the anticonvulsant activity.



Keywords


Doramectin, Pharmacodynamics, Diethyl Ether, Diazepam and Phenytoin

Full Text: PDF

Refbacks

  • There are currently no refbacks.




Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

*2016 Journal Impact Factor was established by dividing the number of articles published in 2014 and 2015 with the number of times they are cited in 2016 based on Google Scholar, Google Search and the Microsoft Academic Search. If ‘A’ is the total number of articles published in 2014 and 2015, and ‘B’ is the number of times these articles were cited in indexed publications during 2016 then, journal impact factor = A/B. To know More: (http://en.wikipedia.org/wiki/Impact_factor)