The Cauvery River is the biggest river in south India. The Cauvery river basin flows through districts such as Nilgiris, Coimbatore, Tirupur, Erode, Dharmapuri, Krishnagiri, Salem, Namakkal, Karur, Dindigul, Pudukottai, Trichirappalli, Perambalur, Ariyalur Thanjavur, Tiruvarur, Cuddalore and Nagapattinam in the state Tamil Nadu. The study area is between latitudes 76” 2’E, 79”8’ E and 12”7’ N, 10”14 N longitudes. The secondary data collected from the Ministry of Micro, Small and Medium enterprises (MSME) and statistical hand book of Cauvery basin districts. The data which collected are Food based, Textile based, Readymade garment and Embroidery, Forest based, Leather based, Chemical based, Plastic & Rubber based, Mineral based, Engineering based, Electrical & Electronics based and others industries. In this article, the industrial combination in the Tamil Nadu Cauvery Basin is outlined, followed by the discussion on the area using Doi’s method industrial combination analysis. The study of industrial combination is very significant for any particular region because it provides an idea about the relative position of industries which is necessary for future development of industries in Tamil Nadu Cauvery basin.