Histological Effects of Chronic Administration of Crude Aqueous Extract of Hibiscus Sabdariffa on the Colon of Wistar Rats
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Histological Effects of Chronic Administration of Crude Aqueous Extract of Hibiscus Sabdariffa on the Colon of Wistar Rats |
| 2. | Creator | Author's name, affiliation, country | Michael Otakhor Erhunmwunse; Department of Anatomy, University of Benin, Benin City; Nigeria |
| 2. | Creator | Author's name, affiliation, country | Daniel Enohense Odiase; Department of Anatomy, University of Benin, Benin City, Nigeria |
| 3. | Subject | Discipline(s) | M.Sc; B.Sc Anatomy |
| 3. | Subject | Keyword(s) | Anti-Inflammation; Colonic Mucosa; Goblet Cells; Induced Effects |
| 3. | Subject | Subject classification | Human Anatomy |
| 4. | Description | Abstract |
Hibiscus sabdariffa (Hs) is used in folk medicine for the treatment such as in gastro diseases and infection. The aim of this study was to investigate the effect of chronic administration of crude aqueous extract of Hs calyces on the colon of adult Wistar rats. Rats of both sexes (n = 32), with average weight of 230 g were randomly selected into three treatment (I, II & III) & Control (IV) groups of eight rats each. Groups I, II & III respectively received daily administration of 250, 500 & 1000 mg/kg of body weight of Hs for 31 days through orogastric tube. The control group received tap water through the same route. All rats were feed with growers mash and given water literally. The rats were subjected to light anesthesia (Chloroform) in a urethane saturated chamber and sacrificed at the 32nd day of the experiment and the stomach and the colon were carefully dissected and quickly fixed in 10% formal saline for histological study. The result revealed that the rats in the treated groups showed heavily packed epithelial cells, with significant increase in the level of goblet cells and mucin secretions in the colon mucosa when compared with the control group. This report provides further evidence that the medicinal components of Hs extract has a potential effect as an anti-inflammatory activity on the Colon. |
| 5. | Publisher | Organizing agency, location | |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (YYYY-MM-DD) | 2014-04-14 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | http://scientific.cloud-journals.com/index.php/IJAPST/article/view/Sci-180 |
| 11. | Source | Journal/conference title; vol., no. (year) | International Journal of Advanced Pharmaceutical Science and Technology; Published Papers |
| 12. | Language | English=en | en |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright Terms & Conditions Authors who publish with this journal agree to the following terms: a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work Cloud Publications reserves the right to amend/change the copyright policy; with/without notice. |