An Experimental Study on Pharmacodynamics Interaction of Doramectin with Anticonvulsants and Anaesthetics in Mice

Abstract

The present study was conducted to examine the pharmacodynamics interactions between doramectin and general anesthetics like diethyl ether and anticonvulsants like phenytoin and diazepam. The methods employed were supramaximal electroshock test (for phenytoin), chemical convulsion test and unconditioned response avoidance test (for diazepam) and different stages of anesthesia and duration of anesthesia (for diethyl ether). In supramaximal electroshock test phenytoin was equally effective in all the groups in controlling grand mal seizures. In chemical convulsion test no response to diazepam was observed in all the groups pretreated with doramectin. And in unconditioned response avoidance test only one mouse showed response to shock in doramectin 200µg/kg group similar to the control 2 group. However, no mouse showed response to shock in doramectin 600 µg/kg groups. No difference was observed in the time taken for exhibiting various stages of anesthesia in different groups in inhalant anesthesia. However the total duration of anesthesia was increased in doramectin (200 mg/kg) treated group (781.67±24.82 sec)) and the value was significantly high in doramectin (600 mg/kg) treated group (861.67±55.69 sec) as compared to 673.33±30.94 sec in control 2. The result suggests that doramectin prolongs the recovery from anesthesia but does not support the anticonvulsant activity.