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Pharmacokinetics of Enrofloxacin after Single Intravenous and Oral Bolus Administration in Broiler Chicken


 
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1. Title Title of document Pharmacokinetics of Enrofloxacin after Single Intravenous and Oral Bolus Administration in Broiler Chicken
 
2. Creator Author's name, affiliation, country P. Mekala; Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal, Tamil Nadu, India
 
2. Creator Author's name, affiliation, country A. Jagadeeswaran; Ethnoveterinary Herbal Research Centre for Poultry, Namakkal, Tamil Nadu India
 
2. Creator Author's name, affiliation, country A. Arivuchelvan; Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal, Tamil Nadu, India
 
2. Creator Author's name, affiliation, country P. Senthilkumar; Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Orathanadu, Tamil Nadu, India
 
2. Creator Author's name, affiliation, country K. Nanjappan; Department of Veterinary Physiology, Veterinary College and Research Institute, Namakkal, Tamil Nadu, India
 
2. Creator Author's name, affiliation, country T.R. Gopala Krishnamurthy; Poultry Disease Diagnosis and Surveillance Laboratory, Namakkal, Tamil Nadu, India
 
3. Subject Discipline(s) Veterinary Science, Veterinary Pharmacologgy and Toxicology
 
3. Subject Keyword(s) Bioavailability; Broiler Chicken; Enrofloxacin; Pharmacokinetics; PK/PD Integration
 
3. Subject Subject classification Pharmacokinetics
 
4. Description Abstract The pharmacokinetics and bioavailability of enrofloxacin was compared in Cobb strain broiler chicken after intravenous and oral administration of enrofloxacin at the rate of 10mg.kg-1. The concentration of enrofloxacin at various time intervals in plasma was determined by HPLC and the pharmacokinetic parameters were calculated by non compartmental approach. AUC was significantly high in i.v. route (32.72±1.15 vs 25.35±1.92mg.h.mL-1)whereas highly significant increase in MRT (15.81±0.54 vs 8.86±0.23h), Vd area (4.69±0.16 vs 3.04±0.09 L.kg-1) and t1/2b (10.57±0.35 vs 6.84±0.15h) were noticed in oral route when compared to i.v. route. The Cmax of 1.63±0.12mg.mL-1 was attained at tmax of 3.58±0.61h and absolute bioavailability was 77.47±5.86% after oral administration. PK/PD integration revealed that the dose (10mg.kg-1) was capable of treating only moderately sensitive organisms with MIC ≤0.125mg.mL-1 and increase in dosage is needed for less sensitive organisms.
 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s) Tamilnadu Veterinary and Animal Sciences University
 
7. Date (YYYY-MM-DD) 2014-07-08
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier http://scientific.cloud-journals.com/index.php/IJAVST/article/view/Sci-190
11. Source Journal/conference title; vol., no. (year) International Journal of Advanced Veterinary Science and Technology; Volume 3 (Year 2014)
 
12. Language English=en en
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
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