A rescued seven-year-old intact female Indian leopard (Panthera pardus fusca) with limited previous history and no known clinical parameters was observed showing severe incoordination and altered mentation. Conscious neurological exam was not feasible, but close observation was possible in a confined area. The leopard exhibited ataxia, right-sided head tilt without nystagmus, dysmetria, reduced jaw tone and disorientation. However, appetite, urine and bowel movements were found to be regular. MRI confirmed the presence of a large, well-circumscribed intracranial mass measuring 3.7x2.9x3.4 cm on the right cerebello-pontine angle region and involving parts of the temporal lobe, cerebellum, brain stem and petrous bone, consistent with a meningioma. The right-sided head tilt, ataxia, dysmetria along with Temporalis and Masseter muscle atrophy suggested involvement of cerebellum, cranial nerves fifth (V), eighth (VIII) and possibly seventh (VII).