Pharmacokinetics of Enrofloxacin after Single Intravenous and Oral Bolus Administration in Broiler Chicken

Abstract

The pharmacokinetics and bioavailability of enrofloxacin was compared in Cobb strain broiler chicken after intravenous and oral administration of enrofloxacin at the rate of 10mg.kg^-1. The concentration of enrofloxacin at various time intervals in plasma was determined by HPLC and the pharmacokinetic parameters were calculated by non compartmental approach. AUC was significantly high in i.v. route (32.72±1.15 vs 25.35±1.92mg.h.mL^-1)whereas highly significant increase in MRT (15.81±0.54 vs 8.86±0.23h), V_{d area} (4.69±0.16 vs 3.04±0.09 L.kg^-1) and t_1/2b (10.57±0.35 vs 6.84±0.15h) were noticed in oral route when compared to i.v. route. The C_max of 1.63±0.12mg.mL^-1 was attained at t_max of 3.58±0.61h and absolute bioavailability was 77.47±5.86% after oral administration. PK/PD integration revealed that the dose (10mg.kg^-1) was capable of treating only moderately sensitive organisms with MIC ≤0.125mg.mL^-1 and increase in dosage is needed for less sensitive organisms.